公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!

抑制剂描述:

产品名称:GPR120 Compound A

产品别名:见爱必信官网

英文别名:GPR120 Compound A

靶点:GPR120

CAS:1599477-75-4

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC₅₀ = ~0.35 μm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1).

溶解性:DMSO : ≥ 50 mg/mL (123.20 mM)

体外研究:

GPR120-IN-1 is fully selective for Gpr120 (logEC₅₀=−7.62) with negligible activity towards Gpr40. GPR120-IN-1 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120-IN-1 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC₅₀s of ~0.35 μM. GPR120-IN-1 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation .

体内研究:GPR120-IN-1 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120-IN-1 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten.

产品信息订购:

产品更多信息请进入爱必信网站咨询