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抑制剂描述:

产品名称:Hemin

产品别名:见爱必信官网

英文别名:Hemin

靶点:Mitophagy;Autophagy

CAS:16009-13-5

纯度:98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Hemin is an iron-containing porphyrin used in the management of porphyria attacks, particularly in acute intermittent porphyria.

溶解性:DMSO : 17.33 mg/mL (26.58 mM; Need ultrasonic)

体外研究:

The addition of hemin (30 μM) depressed the extent of incorporation of phosphate into eIF-2β by about 50%. Concentrations of 25 μM hemin significantly decreased the rate of incorporation of phosphate into eIF-2α. Concentrations of hemin ranged from 20 to 40 μM maintained an optimal rate of protein synthesis in cell lysates.

体内研究:In mice, pretreated with an intraperitoneal injection of hemin displayed a marked induction of HO-1. In hemin-treated mice, thrombus formation was delayed, and the delay was completely blunted by tin protoporphyrin-IX.

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