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抑制剂描述:

产品名称:ICCB280

产品别名:见爱必信官网

英文别名:ICCB280

靶点:

CAS:2041072-41-5

纯度:98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc).

溶解性:DMSO : 83.33 mg/mL (215.66 mM; Need ultrasonic)

体外研究:

ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM. ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells. ICCB280 (10 μM; 7 d) induces granulocytic differentiationand and subsequent apoptosis in HL-60 cells.

体内研究:

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