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抑制剂描述:

产品名称:Icilin

产品别名:见爱必信官网

英文别名:Icilin

靶点:TRP Channel

CAS:36945-98-9

纯度:>97%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel.

溶解性:DMSO : ≥ 54 mg/mL (173.47 mM)

体外研究:

Icilin-evoked TRPM8 currents show variable activation kinetics and Ca²⁺ dependence.Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization.

体内研究:Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin (3 mg/kg; s.c.) induces“Wet dog shake” in mice.

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