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抑制剂描述:

产品名称:ITE

产品别名:见爱必信官网

英文别名:ITE

靶点:AhR

CAS:448906-42-1

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

ITE is an Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM).

溶解性:DMSO : ≥ 41 mg/mL (143.20 mM)

体外研究:

ITE is an endogenous agonist of AhR, binding directly to AHR, with a Ki of 3 nM. ITE (0.03-30 mg/mL) decreases the antigen-specific T-cell proliferative responses. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 μM, but shows no effect at 0.01-5 μM. ITE does not affect cell cycle progress of HPAECs at 10 and 20 μM, or induce expression of cleaved caspase-3 protein in HPAECs at 20 μM. In addition, ITE (20 μM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs.

体内研究:ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice.

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