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抑制剂描述:

产品名称:JSH-23

产品别名:见爱必信官网

英文别名:JSH-23

靶点:NF-kB

CAS:749886-87-1

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC₅₀ of 7.1 μM.

溶解性:DMSO : 45 mg/mL (187.2 mM)
Ethanol :16 mg/mL (66.6 mM)

体外研究:

JSH-23 inhibits LPS-induced nuclear translocation of NF-κB p65 without affecting IκBα degradation. JSH-23 inhibits LPS-induced apoptotic chromatin condensation, while does not show significant cytotoxic effects on the RAW 264.7 cells at JSH-23 also decreases NO production and neuronal migration in LPS activated cultures primary cultures from developing mouse cerebellum. Moreover, JSH-23 augments cisplatin cytotoxicity in ovarian cancer cells with CI values ranging from 0.35 to 0.85.

体内研究:JSH-23 (3 mg/kg) significantly reverses the nerve conduction and nerve blood flow deficits by decreasing neuroinflammation and improving antioxidant defence in diabetic rats.

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