公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!

抑制剂描述:

产品名称:L-Glutamine

产品别名:见爱必信官网

英文别名:L-Glutamine

靶点:mGluR

CAS:56-85-9

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.

溶解性:Water : 27 mg/mL (184.8 mM)

体外研究:

L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-Cit to L-Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells. L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC. L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells. L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2.

体内研究:L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets.

产品信息订购:

产品更多信息请进入爱必信网站咨询