公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!

抑制剂描述:

产品名称:LIT-001

产品别名:见爱必信官网

英文别名:LIT-001

靶点:

CAS:2245072-21-1

纯度:98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC₅₀=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism.

溶解性:DMSO : 250 mg/mL (387.18 mM; Need ultrasonic)

体外研究:

In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only.

体内研究:LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ).

产品信息订购:

产品更多信息请进入爱必信网站咨询