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抑制剂描述:

产品名称:L-Theanine

产品别名:见爱必信官网

英文别名:L-Theanine

靶点:AMPAR

CAS:3081-61-6

纯度:99%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

L-Theanine is an analog of glutamine and one of the components of green tea. L-Theanine binds to AMPA, Kainate, NMDA, and group I mGlu receptors. Modulates the activity of several antitumor drugs. Reportedly stimulates self-renewal of human embryonic stem cells.

溶解性:Water :34 mg/mL (195.17 mM)

体外研究:

L-theanine promotes NO production in endothelial cells. L-Theanine mediated eNOS phosphorylation and NO production are PI3K/ERK pathway dependant. Treatment of EA.hy926 cells with L-theanine dose-dependently increases eNOS Ser1177 phosporylation. This increase occurrs at 2-5 min of L-theanine treatment and coincides with NO production. L-theanine confers neuroprotective effects by increasing the expression levels of PLC-beta1 and gamma1, and thereby minimizes apoptosis in the neural cells.

体内研究:L-theanine can enhance innate immune function by regulating the secretion of immune cytokines. Its administration increases the splenic organ index and decreases the contents of ILs-4/6/10 and the ratio of IL-4/IFN-γ in the serum. High-dose L-theanine administration increases the levels of dopamine and 5-hydroxytryptamine in the pituitary and hippocampus, resulting in decrease in corticosterone level in the serum. L-theanine administration decreases the mRNA expressions of PLC isomers in the liver and PLC-γ1 and PLC-δ1 in the spleen. mRNA expressions of PLC-βf1 in the spleen and PLC isomers mRNA in the heart are up-regulated by L-theanine administration. After being absorbed into the body, L-theanine can penetrate the blood-brain barrier and regulate the secretion of neurotransmitters of central nervous system cells and levels of hormones such as corticosterone (CORT) and adrenaline (EPI) in the serum. L-theanine can increase levels of 5-hydroxytryptamine (5-HT) and noradrenaline, and decrease levels of adrenocorticotropic hormone and CORT in the hippocampus and prefrontal cortex of rats. L-theanine has been implicated in reduction of blood pressure in hypertensive rats. L-theanine could inhibit the glucose uptake by downregulating the related gene expression in the small intestine of rats. Intestinal gene expression of transporters responding to amino acids absorption was stimulated by L-theanine administration.

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