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抑制剂描述:

产品名称:MPP+ iodide

产品别名:见爱必信官网

英文别名:MPP+ iodide

靶点:Others

CAS:36913-39-0

纯度:≥98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

MPP+ iodide is a metabolite of dopaminergic neurotoxin MPTP which stimulates the production of the superoxide radical resulting in apoptosis in PC12 cells. Studies suggest that MPP+ iodide is a selective inhibitor of mitochondrial complex I and it decreases mitochondrial REDOX activity. In addition, GSK-3β is a mediator of MPP+ iodide induced neurotoxicity. Alternate studies indicate that the D-loop of human mtDNA is destabilized by MPP+ iodide via releasing the nascent H-strands of mtDNA.

溶解性:DMSO : 100 mg/mL (336.54 mM; Need ultrasonic)
H2O : 100 mg/mL (336.54 mM; Need ultrasonic)

体外研究:

MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells. MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity.

体内研究:

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