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抑制剂描述:

产品名称:Pimavanserin

产品别名:见爱必信官网

英文别名:Pimavanserin

靶点:5-HT Receptor

CAS:706782-28-7

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:Pimavanserin is a potent and selective serotonin <b>5-HT2A</b> inverse agonist with <b>pIC50</b> of 8.73, used to treat psychosis associated with Parkinson’s disease.

溶解性:DMSO :100mg/mL(99.48mM)
Water :100mg/mL(99.48mM)
Ethanol :100mg/mL(99.48mM)

体外研究:

体内研究:In rats, Pimavanserin (3 mg/kg, p.o.) attenuates DOI-induced head twitches. In mice, Pimavanserin (3 mg/kg, p.o.) significantly attenuates MK-801-induced hyperactivity. In a rat model of parkinsonian tremor, Pimavanserin (40 mg/kg, i.p.) produces a significant overall reduction of tacrine-induced tremulous jaw movements.

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