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- 英文名称：见爱必信官网
- 品牌：爱必信(absin)
- 产地：中国
- 货号：abs810434
- cas：2645-32-1
- 价格： ￥511/瓶
- 发布日期： 2022-04-07
- 更新日期： 2025-12-26
| 产地 | 中国 |
| 品牌 | 爱必信(absin) |
| 货号 | abs810434 |
| 用途 | 见爱必信官网 |
| 包装规格 | 5mg,5mg,5mg,10mg,10mg,10mg,50mg,50mg,50mg,100mg,100mg,100mg |
| 纯度 | >98%% |
| CAS编号 | 2645-32-1 |
| 别名 | 2,6-Diamino-3,5-dithiocyanopyridine; PR 619; PR619 |
| 是否进口 | 否 |
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抑制剂描述: 产品名称:PR-619 产品别名:见爱必信官网 英文别名:PR-619 靶点:DUB CAS:2645-32-1 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. 溶解性:DMSO : ≥ 21 mg/mL (94.05 mM) 体外研究:
PR-619, a deubiquitylase inhibitor, prevents degradation, indicating KCa3.1 is targeted for degradation by ubiquitylation. In PR-619 treated cells, channel degradation is significantly inhibited with 87±1% of KCa3.1 still remaining after 24 hrs (n=3; P. Cell viability is determined by MTT assay and revealed that PR-619 exerted concentration-dependent cytotoxicity in a very narrow concentration range of 7-10 μM. 体内研究:
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