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抑制剂描述:

产品名称:Quinidine

产品别名:见爱必信官网

英文别名:Quinidine

靶点:P450

CAS:56-54-2

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.

溶解性:DMSO : ≥ 50 mg/mL (154.12 mM)

体外研究:

Quinidine is a clinical anti-arrythmic drug which affects ionic currents in heart muscle and which has also been shown to be a potent blocker of several classes of K+ channel in a variety of cell types. Bath application of quinidine causes a dose-dependent reduction of the peak amplitude of Ik. The Kd for blockade of Ik at 0 mV is estimated to be 41 μM. Quinidine elicits a dose-dependent increase of the rate of the decay of Ik and this effect is enhanced by membrane depolarization. Quinidine also causes a 5 mV hyperpolarizing shift of the steady-state inactivation curve and increases the half-time for recovery from inactivation. Quinidine does not affect the onset of inactivation measured at -30 mV.

体内研究:

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