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产地 | 中国 |
品牌 | 爱必信(absin) |
货号 | abs816135 |
用途 | 见爱必信官网 |
英文名称 | 见爱必信官网 |
包装规格 | 5mg,5mg,5mg,25mg,25mg,25mg,50mg,50mg,50mg,100mg,100mg,100mg |
纯度 | >98%% |
CAS编号 | 839707-37-8 |
别名 | Pluripotin |
是否进口 | 否 |
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抑制剂描述: 产品名称:SC1 产品别名:见爱必信官网 英文别名:SC1 靶点:ERK CAS:839707-37-8 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: Pluripotin (SC1) is a dual inhibitor of <b>extracellular signal-regulated kinase 1</b> (ERK1, MAPK3) and <b>RasGAP</b>. Maintains embryonic stem cell (ESC) self-renewal. 溶解性:DMSO : 13.8 mg/mL (25 mM) 体外研究:
SC1 is a dual function small molecule inhibitor of both ERK1 and RasGAP and that simultaneous inhibition of both protein activities is required and sufficient for SC1’s effects on mES cells. SC1 activates Ras by inhibition of RasGAP function. SC1 improved the derivation efficiency and pluripotency of ES cells from C57BL/6. Three types of pluripotent stem cells (fES, ntES, and iPS cells) of the C57BL/6 background could generate full-term pups with high efficiency when cultured with SC1. 体内研究:
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