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抑制剂描述:

产品名称:SC75741

产品别名:见爱必信官网

英文别名:SC75741

靶点:NF-kB

CAS:913822-46-5

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:SC75741 is a broad and efficient NF-κB inhibitor with an IC₅₀ of 200 nM for p65.

溶解性:DMSO : 33 mg/mL (58.3 mM)

体外研究:

SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants.

体内研究:SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection.

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