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抑制剂描述:

产品名称:SF1670

产品别名:见爱必信官网

英文别名:SF1670

靶点:PTEN

CAS:345630-40-2

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

SF1670是一种高度有效且专一的PTEN的抑制剂,其IC₅₀ 为 2 μM。

溶解性:DMSO :30.7 mg/mL (100 mM)

体外研究:

SF1670 shows potent cytotoxicity in HBEC, PC-3, H1299 cells with IC50 of 5 μM, 10 μM, 44 μM, respectively. In a mouse aortic ring matrigel angiogenesis model, SF1670 stimulates the angiogenic processes. SF1670 augments chemoattractant-elicited PtdIns(3,4,5)P3 signaling in neutrophils and enhances neutrophil functions.

体内研究:Pretreatment of SF1670 (500 nM i.v.) augments bacteria-killing capability in neutropenic mice in both peritonitis and bacterial pneumonia, and decreases the mortality of neutropenia-related pneumonia.

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