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- 品牌：爱必信(absin)
- 产地：中国
- 货号：abs810654
- cas：56396-35-1
- 价格： ￥789/瓶
- 发布日期： 2022-04-07
- 更新日期： 2025-09-18
| 产地 | 中国 |
| 品牌 | 爱必信(absin) |
| 货号 | abs810654 |
| 用途 | 见爱必信官网 |
| 英文名称 | 见爱必信官网 |
| 包装规格 | 5mg,5mg,5mg,5mg,10mg,10mg,10mg,10mg,50mg,50mg,50mg,50mg,100mg,100mg,100mg,100mg |
| 纯度 | >98%% |
| CAS编号 | 56396-35-1 |
| 是否进口 | 否 |
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公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:UK-5099 产品别名:见爱必信官网 英文别名:UK-5099 靶点:MPC CAS:56396-35-1 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述:UK-5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC). 溶解性:DMSO : ≥ 50 mg/mL (173.43 mM) 体外研究:
UK-5099 covalently binds to Mpc and blocks pyruvate transport. UK-5099 enhances aerobic glycolysis and decreases mitochondrial oxidative phosphorylation in LnCap cell in vitro, which is accompanied by increasing proportion of side population (SP) fraction, higher level of stemness markers expression and exhibiting high resistance to chemotherapy. UK5099 enhances stem-like phenotype of prostatic cancer cell through metabolic shift from oxidative phosphorylation to aerobic glycolysis. UK-5099 suppresses proliferation and arrested LnCap cell cycle at G1/G0. 体内研究:UK-5099 slows the growth of patient-derived xenograft (PDX) tumors in mice without severe loss of animal body weight.
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- 手机：18438616290