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抑制剂描述:

产品名称:UNC-0638

产品别名:见爱必信官网

英文别名:UNC-0638

靶点:Histone Methyltransferase

CAS:1255580-76-7;1255517-77-1

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets.

溶解性:Ethanol :93 mg/mL (182.4 mM)
DMSO :93 mg/mL (182.4 mM)
Water :6 mg/mL (11.77 mM)

体外研究:

UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP, with a toxicity/function ratio of >100, compared to

体内研究:In mouse drug metabolism and pharmacokinetic studies, UNC0638 had high clearance, short half-life, high volume distribution and low exposure after intravenous, oral or intraperitoneal administration. Thus, although UNC0638 is probably not suitable for in vivo animal studies owing to low exposure levels, its high stability under cellular assay conditions, in combination with high potency and selectivity, makes UNC0638 an ideal chemical tool for cell-based studies.

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