|
- 品牌：爱必信(absin)
- 产地：中国
- 货号：abs810636
- cas：1048371-03-4
- 价格： ￥824/瓶
- 发布日期： 2022-04-07
- 更新日期： 2025-09-18
| 产地 | 中国 |
| 品牌 | 爱必信(absin) |
| 货号 | abs810636 |
| 用途 | 见爱必信官网 |
| 英文名称 | 见爱必信官网 |
| 包装规格 | 5mg,5mg,10mg,10mg,50mg,50mg,100mg,100mg |
| 纯度 | >98%% |
| CAS编号 | 1048371-03-4 |
| 别名 | UPF1069; UPF1069 |
| 是否进口 | 否 |
|
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:UPF1069 产品别名:见爱必信官网 英文别名:UPF1069 靶点:PARP CAS:1048371-03-4 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述:UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1. 溶解性:DMSO 56 mg/mL (200.5 mM) 体外研究:
UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM. 体内研究:In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
产品信息订购:
|
- 手机：18438616290