公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!

抑制剂描述:

产品名称:VER155008

产品别名:见爱必信官网

英文别名:VER155008

靶点:HSP

CAS:1134156-31-2

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

VER-155008 is a potent <b>Hsp70</b> family inhibitor with <b>IC₅₀</b> of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

溶解性:DMSO : ≥ 37 mg/mL (66.50 mM)

体外研究:

VER-155008 inhibits the proliferation of human breast and colon cancer cell lines BT474, MB-468, HCT116, and HT29 with GI50s in the range 5.3-14.4 μM, and induces Hsp90 client protein degradation in both HCT116 and BT474 cells. In the 8505C and FRO cells, VER-155008 reduces the cell viability and elevates the percentage of dead cells in a time- and dose- dependent manner. VER-155008 causes a dose-dependent inhibition of cytokine-dependent AML cell proliferation. VER-155008?shows an effective inhibition of cell proliferation in A549 and H1975 cells.

体内研究:In HCT116 tumor bearing mice, VER-155008 (25 or 40 mg/kg, i.v.) demonstrates rapid metabolism and clearance, along with tumor levels below the predicted pharmacologically active level.

产品信息订购:

产品更多信息请进入爱必信网站咨询