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抑制剂描述:

产品名称:Vorasidenib

产品别名:见爱必信官网

英文别名:Vorasidenib

靶点:IDH

CAS:1644545-52-7

纯度:98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Vorasidenib 是一个非特异的异柠檬酸脱氢酶 (IDH) 抑制剂。

溶解性:DMSO : ≥ 125 mg/mL (301.39 mM)

体外研究:

Vorasidenib has recently entered phase 1 clinical trials in hematologic (NCT02492737) and solid malignancies (NCT02481154) in patients with either an IDH1 or an IDH2 mutation. Preclinical studies have suggested that Vorasidenib fully penetrates the blood-brain barrier and may be a more effective option for patients with IDH1/2 mutated glioma.

体内研究:

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