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抑制剂描述:

产品名称:ZM241385

产品别名:见爱必信官网

英文别名:ZM241385

靶点:Adenosine Receptor

CAS:139180-30-6

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:ZM-241385 is a high affinity antagonist ligand selective for the <b>adenosine A2A receptor</b>.

溶解性:DMSO : ≥ 30 mg/mL (88.93 mM)

体外研究:

ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7 min) OGD period, and protect CA1 neuron and astrocyte from injury.

体内研究:ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists.

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