公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!

抑制剂描述:

产品名称:Fluoxetine hydrochloride

产品别名:见爱必信

英文别名:Fluoxetine hydrochloride

靶点:SSRIs

CAS:56296-78-7

纯度:99%

外观:见爱必信

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

溶解性:DMSO : 34.6 mg/mL (100 mM)
water : 3.5 mg/mL (10 mM)

体外研究:

Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration.

体内研究:Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in male Sprague–Dawley rats. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ((ex)) and norepinephrine ((ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone.

产品信息订购:

产品更多信息请进入爱必信网站咨询