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抑制剂描述:

产品名称:KN-62

产品别名:见爱必信

英文别名:KN-62

靶点:P2X Receptor

CAS:127191-97-3

纯度:>98%

外观:见爱必信

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

KN-62是可渗透入细胞的CaM激酶II抑制剂,IC50为0.9 μM,直接与该酶的钙调蛋白结合位点结合,同时还是非竞争性P2X7受体拮抗剂,IC50为15 nM。

溶解性:DMSO : 72.2 mg/mL (100 mM)

体外研究:

KN-62 suppresses the A23187-induced autophosphorylation of Ca2+/CaM kinase in PC12 D cells. KN-62 (10 μM) inhibits carbachol and potassium-stimulated insulin secretion from rat pancreatic islets. KN-62 also inhibits growth of K562 cells and blocks cell cycle progression.

体内研究:KN-62 inhibits seizure-induced expression of brain-derived neurotrophic factor mRNA in rat brain.

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