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抑制剂描述:

产品名称:ZCL 278

产品别名:见爱必信官网

英文别名:ZCL 278

靶点:Ras

CAS:587841-73-4

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

 ZCL278 是一种选择性的 Cdc42 调节剂,直接结合到 Cdc42,且抑制其功能,Kd 为 11.4 μM。

溶解性:DMSO : 50 mg/mL (85.49 mM; Need ultrasonic)

体外研究:

ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity.

体内研究:ZCL278 reduces the JUNV RNA load in the spleen more than 33-fold, with JUNV RNA being undetectable in 5 out of 8 mice. These results are similar to those seen in Gabapentin-treated mice, demonstrating that ZCL278 can abrogate JUNV replication.

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