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抑制剂描述:

产品名称:Tempol

产品别名:见爱必信官网

英文别名:Tempol

靶点:ROS

CAS:2226-96-2

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Tempol是一种超氧化物清除剂,具有神经保护,抗炎症和镇痛效果。

溶解性:DMSO : 17.2 mg/mL (100 mM)
Ethanol : 17.2 mg/mL (100 mM)

体外研究:

Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner.

体内研究:Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. Tempol prevents cerebral vessel remodeling in hypertensive rats. Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats.

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