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- 品牌：爱必信(absin)
- 产地：中国
- 货号：abs816995
- cas：13171-25-0
- 价格： ￥358/瓶
- 发布日期： 2022-04-07
- 更新日期： 2025-09-18
| 产地 | 中国 |
| 品牌 | 爱必信(absin) |
| 货号 | abs816995 |
| 用途 | 见爱必信官网 |
| 英文名称 | 见爱必信官网 |
| 包装规格 | 25mg,25mg,25mg,100mg,100mg,100mg,50mg,50mg,50mg,200mg,200mg,200mg |
| 纯度 | 99%% |
| CAS编号 | 13171-25-0 |
| 别名 | 盐酸曲美他嗪 |
| 是否进口 | 否 |
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公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:Trimetazidine dihydrochloride 产品别名:见爱必信官网 英文别名:Trimetazidine dihydrochloride 靶点:Mitochondrial Metabolism CAS:13171-25-0 纯度:99% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: Trimetazidine dihydrochloride is a drug for angina pectoris. Trimetazidine is the first cytoprotective anti-ischemic agent , which improves myocardial glucose utilization through inhibition of fatty acid metabolism. 溶解性:DMSO : 67 mg/mL (197.49 mM) 体外研究:
Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion. 体内研究:The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia.
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- 手机：18438616290