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抑制剂描述:

产品名称:Tyrphostin A9

产品别名:见爱必信官网

英文别名:Tyrphostin A9

靶点:PDGFR

CAS:10537-47-0

纯度:98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

 Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC₅₀ of 460 μM, but is also found to be more potent to PDGFR with IC₅₀ of 0.5 μM.

溶解性:Ethanol :56mg/mL(198.31mM)
DMSO :56mg/ml(198.31 mM)

体外研究:

SF 6847 inhibits the replication of herpes simplex virus type 1 (HSV-1) with IC50 of 40 nM. SF 6847 (50 nM) partly reverses sodium orthovanadate induced HSV-1 plaque formation. SF 6847 ( SF 6847 prevents PDGF-induced tyrosine phosphorylation of LRP in caveolae in human fibroblasts suggesting that PDGF-BB-mediated LRP activation requires tyrosine phosphorylation and therefore activation of PDGFR-β. SF 6847 (1 mM) blocks the strain-induced stimulatory effect on DNA synthesis of fetal lung cells. SF 6847 (1 μM) causes increased exon inclusion of MAPT exon 10. SF 6847 does not affect the translation or stability of the two mRNAs. SF 6847 (1.6 μM) increases the inclusion of MAPT exon 10 by 2-fold in SHSY-5Y cells.

体内研究:

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