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抑制剂描述:

产品名称:Pamidronate disodium salt

产品别名:见爱必信官网

英文别名:Pamidronate disodium salt

靶点:FPPS;HAP

CAS:57248-88-1

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Pamidronate Disodium是一种含氮的双磷酸盐类药物,用于预防骨质疏松症。

溶解性:Water :50 mg/mL

体外研究:

Pamidronate increases OPG mRNA levels and protein secretion by hOB by up to 2- to 3-fold in a dose-dependent fashion with a maximum effect at 1 μM after 72 hours. Artemisinin prevents the inhibitory effects of the glucocorticoid dexamethasone on OPG mRNA and protein production. Pamidronate induces type I collagen secretion and alkaline phosphatase activity by 2-fold. Pamidronate has a more pronounced calcium-lowering action than etidronate (etidronic acid) and clodronate (clodronic acid) and provides a longer period of normocalcaemic remission. Pamidronate (APD) dose-dependently inhibits resorption of calcium phosphate films by equine OCLs with an IC(50) of 0.58 μM in one horse. Pamidronate also dose-dependently inhibits the number of OCLs present in BM cultures after 7 days.

体内研究:Pamidronate administration significantly suppresses this increase below the control level in the tibia and distal femur of oophorectomized rats. Pamidronate significantly increases bone density and ash weight in both sham-operated and oophorectomized rats. Pamidronate inhibits all significant effects of growth hormone (GH) and it also decreases the IGF-I levels in rats treated with growth hormone (GH). Pamidronate itself results in increased the bone density and ash weight of the tibia and decreased urinary DPD excretion.

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