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抑制剂描述:

产品名称:Pioglitazone

产品别名:见爱必信官网

英文别名:Pioglitazone

靶点:PPAR

CAS:111025-46-8

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

溶解性:DMSO : 15 mg/mL (42.08 mM)

体外研究:

Pioglitazone?is?metabolised?mainly by?CYP2C8?and to a lesser extent by?CYP3A4?in?vitro.?

体内研究:Pioglitazone?significantly attenuates left?ventricular?(LV) cavity dilatation and dysfunction by echocardiography as well as LV end-diastolic pressure?in mice with extensive anterior myocardial?infarction.?Pioglitazone partially normalizes LV dP/dt(max) and dP/dt(min), indices of LV contractile function, which are significantly reduced in MI mice. Pioglitazone?results in a reduced activation?of microglia, reduced?induction?of?iNOS-positive cells and less glial fibrillary acidic protein positive cells in both striatum and substantia nigra pars compacta of MPTP mouse?model?of?Parkinson's?disease. Pioglitazone?almost completely blocks staining of TH-positive neurons for nitrotyrosine, a marker of NO-mediated cell damage.? Pioglitazone?(approximately 20 mg/kg/day) attenuates the MPTP-induced glial activation and prevents the dopaminergic cell loss in the substantia nigra pars compacta (SNpc) in MPTP mouse?model?of?Parkinson's?disease. Pioglitazone results in a reduction in the number of activated microglia and reactive astrocytes in the hippocampus and cortex of 10-month-old?APPV717I?transgenic mice.?Pioglitazone treatment?reduces the expression of the proinflammatory enzymes cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS).?Pioglitazone decreases beta-secretase-1 (BACE1) mRNA and protein?levels, and also a 27% reduction in the?levels?of soluble?Abeta1-42?peptide.?

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