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- 品牌：爱必信(absin)
- 产地：中国
- 货号：abs810337
- cas：483367-10-8
- 价格： ￥1233/瓶
- 发布日期： 2022-04-07
- 更新日期： 2025-07-20
| 产地 | 中国 |
| 品牌 | 爱必信(absin) |
| 货号 | abs810337 |
| 用途 | 见爱必信官网 |
| 英文名称 | 见爱必信官网 |
| 包装规格 | 5mg,5mg,5mg,5mg,10mg,10mg,10mg,10mg,50mg,50mg,50mg,50mg,100mg,100mg,100mg,100mg |
| 纯度 | >98%% |
| CAS编号 | 483367-10-8 |
| 别名 | 嘌呤胺;Shh Signaling Antagonist VI |
| 是否进口 | 否 |
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公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:Purmorphamine 产品别名:见爱必信官网 英文别名:Purmorphamine 靶点:Smo CAS:483367-10-8 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. 溶解性:DMSO : 52.1 mg/mL (100 mM) 体外研究:
Purmorphamine activates the Hedgehog pathway by directly binds and activates Smoothened with IC50 of ~ 1.5 μM in compete with cyclopamine, a Smo antagonist. Purmorphamine is a potent inducer of osteogenesis in multipotent C3H10T1/2 cells. The EC50 (based on ALP expression) for Purmorphamine is 1 μM in C3H10T1/2 cells. Purmorphamine (1 μM) and BMP-4 (100 ng/mL) together increase ALP activity more than 90-fold in 3T3-L1 cells. In contrast to BMP-4, Purmorphamine induces osteogenesis by activating Hedgehog signaling in multipotent mesenchymal progenitor cells. 体内研究:Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats.
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