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- 品牌：爱必信(absin)
- 产地：中国
- 货号：abs810727
- cas：388082-78-8
- 价格： ￥403/瓶
- 发布日期： 2022-04-07
- 更新日期： 2025-03-28
| 产地 | 中国 |
| 品牌 | 爱必信(absin) |
| 货号 | abs810727 |
| 用途 | 见爱必信官网 |
| 英文名称 | 见爱必信官网 |
| 包装规格 | 25mg,25mg,25mg,50mg,50mg,50mg,100mg,100mg,100mg |
| 纯度 | >98%% |
| CAS编号 | 388082-78-8 |
| 别名 | 二甲苯磺酸拉帕替尼水合物;GW572016 ditosylate monohydrate; GW2016 ditosylate monohydrate |
| 是否进口 | 否 |
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抑制剂描述: 产品名称:Lapatinib ditosylate monohydrate 产品别名:见爱必信官网 英文别名:Lapatinib ditosylate monohydrate 靶点:EGFR CAS:388082-78-8 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述:Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. 溶解性:DMSO : 91 mg/mL (96.5 mM) 体外研究:
Lapatinib (GW2016; 0.03-10 μM; 6 hours; BT474 and HN5 cells) treatment inhibits receptor autophosphorylation of EGFR and ErbB-2 in a dose-responsive manner. Phosphorylation of serine 473 of AKT was inhibited by GW2016 in a dose-dependent manner. 体内研究:Lapatinib (GW2016; 30-100 mg/kg; oral administration; twice daily; for 21 days; CD-1 nude female mice) treatment inhibits tumor xenograft growth of the HN5 cells in a dose-responsive manner at 30 and 100 mg/kg, with complete inhibition of tumor growth at the higher dose.
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- 手机：18438616290