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抑制剂描述:

产品名称:Leptomycin B

产品别名:见爱必信官网

英文别名:Leptomycin B

靶点:CRM1

CAS:87081-35-4

纯度:≥98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins (export factors). By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation.3 Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomyces sp..

溶解性:Ethanol : 50 mg/ml
Methanol : 50 mg/ml

体外研究:

体内研究:

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