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抑制剂描述:

产品名称:Methylene Blue

产品别名:见爱必信官网

英文别名:Methylene Blue

靶点:Dye Reagent

CAS:61-73-4

纯度:97%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:Methylene Blue is used as a dye in chromoendoscopy. It Inhibits <b>tau filament formation</b> with <b>IC50</b> of 1.9μM. Also it inhibits <b>soluble guanylyl cyclase</b>.

溶解性:DMSO :63mg/mLwarming(196.96mM)
Water :63mg/mLwarming(196.96mM)
Ethanol :10mg/mLwarming(31.26mM)

体外研究:

MB may inhibit the action of nitric oxide synthase itself and could also inactivate nitric oxide directly, possibly through the generation of superoxide anions. In addition to interfering with the nitric oxide–cyclic guanosine monophosphate pathway, MB has also been shown to directly activate calcium-dependent potassium channels and to enhance release of noradrenaline from intracellular stores.

体内研究:Methylene Blue acts by inhibiting guanylate cyclase, thus decreasing C-GMP and vascular smooth muscle relaxation. When injected intravenously, MB selectively accumulates in parathyroid glands, thereby facilitating the identification of these structures during surgery. Pharmacokinetic studies in rodents revealed that intravascular administration of MB leads to a rapid and extensive accumulation of this drug in the central nervous system (CNS).

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