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抑制剂描述:

产品名称:EIPA

产品别名:见爱必信官网

英文别名:EIPA

靶点:Sodium Channel;TRP Channel

CAS:1154-25-2

纯度:98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:EIPA is a TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.

溶解性:DMSO : 140 mg/mL (467.04 mM; Need ultrasonic)

体外研究:

In the presence of 100 μM EIPA, 10 μM benzamil, and 10 μM phenamil, 45Ca2+ uptake decreases from 79±9 to 46±4 (58% remaining), 27±4 (34%), 29±5 (37%), and 38±4 (48%) pmol/oocyte/30 min (n=6, P=0.008), respectively. It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143±8 (n=36), 10.5±2.2 (n=28), 1.1±0.3 (n=30), and 0.14±0.04 μM (n=25), respectively. The number of autophagic vacuoles increases dramatically in the HAE and HPE groups after EIPA treatment compare with the HAN and HPN groups. EIPA regulates the initiation and maturation of the autophagy associated with amino acids in IEC-18 cells. In addition, the uptake of cinnamoylphenazine (CA-PZ) and neutral red (NR) is inhibited by EIPA.

体内研究:

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