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抑制剂描述:

产品名称:Bucladesine Sodium Salt

产品别名:见爱必信官网

英文别名:Bucladesine Sodium Salt

靶点:PKA

CAS:16980-89-5

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Bucladesine Sodium Salt是一种,膜渗透性的选择性PKA激动剂,在PC12细胞中,通过Ca²⁺-和PKA-依赖的方式激活细胞外信号调节激酶(ERK),显著上调ChAT和VAChT基因表达。

溶解性:DMSO :49.1 mg/mL (100 mM)
Water :49.1 mg/mL (100 mM)

体外研究:

Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation.

体内研究:In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments.

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