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抑制剂描述:

产品名称:Clenbuterol hydrochloride

产品别名:见爱必信官网

英文别名:Clenbuterol hydrochloride

靶点:Adrenergic Receptor

CAS:21898-19-1

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

Clenbuterol Hydrochloride is a sympathomimetic β2-adrenoceptor agonist that has been used as a bronchodilator in the treatment of pulmonary diseases such as asthma. At higher doses, clenbuterol acts as an anabolic steroid, favoring skeletal muscle protein synthesis at the expense of fat deposition.

溶解性:DMSO

体外研究:

Clenbuterol increases lipolysis in rat primary adipocytes compared with control. Free glycerol release into the culture medium is 158% and 190% of control values in cultures containing 0.1, or 1 μM Clenbuterol, respectively.

体内研究:Clenbuterol has been shown to decrease body fat in animals and can induce apoptosis in adipose tissue in mice. In red and white muscles, Clenbuterol induces reductions in mitochondrial content, proteins involved in fatty acid transport oxidation, glucose transport, lactate transport, monocarboxylate transporter, and pyruvate oxidation. These extensive metabolic changes induced by Clenbuterol are associated with reductions in PGC-1α and increases in RIP140. Repeated administration of the centrally acting beta adrenoceptor agonist, Clenbuterol, to rats reduces the ability of isoproterenol to increase the concentration of cyclic AMP (cAMP) in slices of cerebellum. This reduced responsiveness to isoproterenol is accompanied by a marked reduction in the density of beta adrenoceptors. In normal soleus muscle, Clenbuterol treatment stimulates protein synthesis, inhibits Ca2+-dependent proteolysis, and increases the levels of calpastatin protein. On the other hand, the administration of Clenbuterol to DEN rats ameliorates the loss of muscle mass, enhances the rate of protein synthesis, attenuates hyperactivation of proteasomal and lysosomal proteolysis, and suppresses the transcription of the lysosomal protease cathepsin L and of atrogin-1/MAFbx and MuRF1.

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