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抑制剂描述:

产品名称:AEBSF hydrochloride

产品别名:见爱必信官网

英文别名:AEBSF hydrochloride

靶点:Thrombin

CAS:30827-99-7

纯度:>98%

外观:见爱必信官网

保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

描述:

AEBSF是水溶性的,不可逆的丝氨酸蛋白酶抑制剂,抑制蛋白酶如胰凝乳蛋白酶,激肽释放酶,血纤维蛋白溶酶,凝血酶,胰蛋白酶。

溶解性:DMSO :24 mg/mL (100 mM)
Water:24 mg/mL (100 mM)

体外研究:

AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.

体内研究:AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.

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