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试剂描述:

产品名称:C-peptide fragment 3-33

产品别名:

CAS号:33017-11-7

英文别名:C-peptide fragment 3-33

分子量:3020.3

分子式:C₁₂₉H₂₁₁N₃₅O₄₈

纯度: ≥ 95%

外观:见爱必信官网

保存方法:-20°C,1 year

描述:C-peptide is cleaved from proinsulin, stored in secretory granules, and eventually released into the bloodstream in amounts equimolar with those of insulin. The measurement of the C-peptide is an important test for the β?cell function. In the red blood cells of type 2 diabetic patients, Na+,K+ ATPase activity is strongly related to blood C-peptide levels. C-peptide signal transduction in human renal tubular cells involves the activation of phospholipase C and PKC-d and PKC-varepsilon, as well as RhoA, followed by phosphorylation of ERK1/2 and JNK and a parallel activation of Akt. C-peptide shows specific binding to a G-protein-coupled membrane binding site, resulting in Ca2+ influx, activation of mitogen-activated protein kinase signalling pathways and stimulation of Na+, K+ ATPase and endothelial nitric oxide synthase.

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