产地 | 中国 |
品牌 | 爱必信(absin) |
货号 | abs813798 |
英文名称 | 见爱必信官网 |
纯度 | >98%% |
CAS编号 | 1135695-98-5 |
别名 | Q-VD-OPh, 1135695-98-5 |
规格 | 1mg,1mg,1mg,5mg,5mg,5mg,10mg,10mg,10mg |
是否进口 | 否 |
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产品描述: 产品名称:Q-VD-OPh 靶点: Caspase CAS号: 1135695-98-5 描述: Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. 英文别名: QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone 外观: white to light brown powder In vitro(体外研究): Q-VD-OPh is a potent inhibitor of caspase-7 with an IC50 of 48 nM utilizing a cell-free assay consisting of human recombinant caspase-7, Q-VD-OPh, and the substrate AMC-DEVD-pNa. Q-VD-OPh fully inhibits caspase-3 and -7 activity at 0.05 μM. Caspase-8 is also inhibited at low Q-VD-OPh concentrations. The cleavage of PARP-1 is fully prevented at 10 μM Q-VD-OPh. DNA fragmentation and disruption of the cell membrane functionality are both prevented at 2 μM Q-VD-OPh. Q-VD-OPh is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk, and is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase12. Q-VD-OPh is not toxic to cells even at extremely high concentrations. QVD is also able to increase the expression of differentiation markers in acute myeloid leukemia (AmL) blasts. QVD alone or combined with VDDs increases differentiation and HPK1-cJun signaling in AmL cell context-dependent manner. 分子式: C26H25F2N3O6 In vivo(体内研究): Chronic treatment with Q-VD-OPh prevents caspase-7 activation and limits the pathological changes associated with tau, including caspase cleavage. Q-VD-OPh could be a potential therapeutic compound for the treatment of Alzheimer's disease. 分子量: 513.49 纯度: >98% 储存/保存方法: store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 可溶性/溶解性: DMSO : 100 mg/mL (194.75 mM; Need ultrasonic)
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