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产品描述:

产品名称:2-HBA

靶点: Caspase-3;Caspase-10

CAS号: 131359-24-5

描述: 2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

外观: white to beige powder

In vitro(体外研究): When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10.

分子式: C₁₇H₁₄O₃

分子量: 266.29

纯度: 98%

储存/保存方法: store at -20℃ for one year(Powder)

可溶性/溶解性: DMSO : 100 mg/mL (375.53 mM; Need ultrasonic)

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