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抗体描述:

产品名称:Rabbit anti-RAD1 Polyclonal Antibody

产品别名:RAD1抗体  

宿主:Rabbit

反应种属:Human;Mouse

克隆性:Polyclonal Antibody

保存方法:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

产品描述:Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity.

用途范围: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

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