TR2; HveA; HVEM; TNFRSF14

HEK 293

Detects a band of approximately 30,43 kDa(Predicted molecular weight:19.0 kDa)

Lyophilized Powder

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

C-10His

＞95% by SDS-PAGE

<1EU/ug

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. It is also known as CD270 in the cluster of differentiation classification. Moreover, it is also referred to as ATAR (another TRAF-associated receptor). The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response. Mutations in this gene have been recurrently been associated to cases of diffuse large B-cell lymphoma and pediatric-type follicular lymphoma. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism.

Q92956