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试剂描述:

产品名称:Apoptolidin

产品别名:

CAS号:194874-06-1

英文别名:Apoptolidin

分子量:1129.4

分子式:C₅₈H₉₆O₂₁

纯度:>95%

外观:见爱必信官网

保存方法:Store at -20° C

描述:Apoptolidin is a selective polyketide, apoptosis inducer produced by Nocardiopsis mainly inducing cell death in E1A-transformed cells and inhibiting the enzymatic activity of mitochondrial F₀F₁-ATPase. In addition, studies suggest that apoptolidin isomerizes in solution into isoapoptolidin within the time frame of most cell-based assays, however isoapoptolidin's ability to inhibit mitochondrial F₀F₁--ATPase is over 10 fold less effective. Furthermore, studies show that apoptolidin induced apoptosis can be inhibited by BCL-2.

应用:An apoptotic cell death inducer

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