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bpV(phen);42494-73-5
  • 品牌:爱必信(absin)
  • 产地:上海
  • 型号:25mg
  • 货号:abs823441
  • cas:42494-73-5
  • 价格: ¥1950/瓶
  • 发布日期: 2023-07-19
  • 更新日期: 2024-06-14
产品详请
产地 上海
品牌 爱必信(absin)
货号 abs823441
用途 -
纯度 ≥98%%
CAS编号 42494-73-5
规格 25mg
是否进口

描述:bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.

储存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.

外观:Yellow to orange solid

可溶性/溶解性:H2O : 18.18 mg/mL (44.97 mM)

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