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试剂描述:

产品名称:单唾液酸四己糖神经节苷脂

产品别名:

CAS号:59247-13-1

英文别名:单唾液酸四己糖神经节苷脂

分子量:2126.3 (non-salt)

分子式:C₉₅H₁₆₂N₅O₄₇?3Na

纯度:≥98%

外观:见爱必信官网

保存方法:Store at -20° C

描述:Ganglioside GT1b trisodium salt (bovine brain) is an alkaline preparation of ganglioside GT1b, a glycosphingolipid-containing small molecule with potent neuroprotective function. Ganglioside GT1b is described to block glutamate-receptor-mediated activation and translocation of protein kinase C, interrupting the increase of neuronal Ca²⁺ influx correlated with this translocation, and inhibiting the subsequent neurotoxicity presented by this Ca²⁺ influx. Ganglioside GT1b is demonstrated to protect mouse brain cells against L-cysteine-induced damage of mitochondrial DNA and increased lipid peroxidation, suggested to operate through scavenging of OH radicals promoted by L-cysteine. Ganglioside GT1b is also demonstrated to suppress seizures, damage to mitochondrial DNA and lipid peroxidation induced by kainic acid.

应用:A glycosphingolipid neuroprotectant

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