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产地 | 上海 |
品牌 | 爱必信(absin) |
货号 | abs42001540 |
用途 | A substrate for assaying CYP2C19 polymorphism |
产品规格 | 5mg |
CAS编号 | 70989-04-7 |
纯度 | 0.98% |
是否进口 | 否 |
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试剂描述: 产品名称:(S)-(+)-美芬妥英 产品别名: CAS号:70989-04-7 英文别名:(S)-(+)-美芬妥英 分子量:218.25 分子式:C12H14N2O2 纯度:≥98% 外观:见爱必信官网 保存方法:-20°C,2 years 描述:(S)-Mephenytoin is a hydantoin small molecule, originally discovered and implemented for its anticonvulsant effects. Individuals present a variable ability to perform hydroxylation of (S)-Mephenytoin at the 4'-position associated with polymorphism in CYP2C19, an oxidase in the cytochrome P-450 system. The poor metabolizer phenotype, those incapable of metabolizing (S)-Mephenytoin by 4'-hydroxylation, also show a reduced ability to clear other pharmaceuticals and xenobiotics, and this (S)-Mephenytoin metabolism experiment has been used to explore the implications of this common phenotypic condition in drug design and toxicity expectations. (S)-Mephenytoin is a substrate of CYP2B6 and CYP2C19. 应用:A substrate for assaying CYP2C19 polymorphism
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