|用途||A substrate for assaying CYP2C19 polymorphism|
描述:(S)-Mephenytoin is a hydantoin small molecule, originally discovered and implemented for its anticonvulsant effects. Individuals present a variable ability to perform hydroxylation of (S)-Mephenytoin at the 4'-position associated with polymorphism in CYP2C19, an oxidase in the cytochrome P-450 system. The poor metabolizer phenotype, those incapable of metabolizing (S)-Mephenytoin by 4'-hydroxylation, also show a reduced ability to clear other pharmaceuticals and xenobiotics, and this (S)-Mephenytoin metabolism experiment has been used to explore the implications of this common phenotypic condition in drug design and toxicity expectations. (S)-Mephenytoin is a substrate of CYP2B6 and CYP2C19.
应用:A substrate for assaying CYP2C19 polymorphism