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试剂描述:

产品名称:(S)-(+)-美芬妥英

产品别名:

CAS号:70989-04-7

英文别名:(S)-(+)-美芬妥英

分子量:218.25

分子式:C₁₂H₁₄N₂O₂

纯度:≥98%

外观:见爱必信官网

保存方法:-20°C,2 years

描述:(S)-Mephenytoin is a hydantoin small molecule, originally discovered and implemented for its anticonvulsant effects. Individuals present a variable ability to perform hydroxylation of (S)-Mephenytoin at the 4'-position associated with polymorphism in CYP2C19, an oxidase in the cytochrome P-450 system. The poor metabolizer phenotype, those incapable of metabolizing (S)-Mephenytoin by 4'-hydroxylation, also show a reduced ability to clear other pharmaceuticals and xenobiotics, and this (S)-Mephenytoin metabolism experiment has been used to explore the implications of this common phenotypic condition in drug design and toxicity expectations. (S)-Mephenytoin is a substrate of CYP2B6 and CYP2C19.

应用:A substrate for assaying CYP2C19 polymorphism

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