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试剂描述:

产品名称:福斯高林1,9-二脱氧

产品别名:

CAS号:64657-18-7

英文别名:福斯高林1,9-二脱氧

分子量:378.50

分子式:C₂₂H₃₄O₅

纯度:≥95%

外观:见爱必信官网

保存方法:Store at -20° C

描述:1,9-Dideoxyforskolin is a derivative of Forskolin which unlike the parent compound is incapable of activating adenylate cyclase. Forskolin-induced stimulation of adenylate cyclase and increased cAMP levels is employed to study the modulation of ion channels and cAMP-dependent second messenger systems, and 1,9-Dideoxyforskolin serves as a negative control for cAMP-related Forskolin inductions. 1,9-Dideoxyforskolin mimics some activity of Forskolin, demonstrating alteration of K⁺ channel activity, reversal of doxorubicin resistance in multidrug resistant sarcoma cells, protection against TNF-α-mediated cytotoxicity, and desensitization at GABA_A receptors.

应用:A Forskolin analog that does not activate adenylate cyclase

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