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试剂描述:

产品名称:1,2-双(庚酰硫基)甘油胆碱磷酸

产品别名:

CAS号:89019-63-6

英文别名:1,2-双(庚酰硫基)甘油胆碱磷酸

分子量:513.7

分子式:C₂₂H₄₄NO₆PS₂

纯度:98%

外观:见爱必信官网

保存方法:Store at -20° C

描述:1,2-bis(Heptanoylthio)glycerophosphocholine is a synthetic thiol phosphoglyceride lipid derived from D-mannitol which functions as a substrate for PLA₂ (phospholipase A₂). Hydrolysis of 1,2-bis(Heptanoylthio)glycerophosphocholine by PLA₂ produces free thiols, which may be derivitized with dithionitrobenzoic acid to form the chromophore for a spectrophotometric assay of intracellular and membrane-bound PLA₂ activity. Release of Arachidonic Acid from membrane phospholipids mediated by PLA₂ is thought to regulate eicosanoid production and marked PLA₂ activity is observed in correlation with inflammation states. Inhibitors of PLA₂ activity, presenting potential intervention upon the inflammatory role of PLA₂, have been identified using this assay design. 1,2-bis(Heptanoylthio)glycerophosphocholine is a substrate of PLA1.

应用:A lipid tool for assay of PLA2 activity

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