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试剂描述:

产品名称:4Alpha-佛波-13-乙酸-12-豆蔻酸酯

产品别名:

CAS号:63597-44-4

英文别名:4Alpha-佛波-13-乙酸-12-豆蔻酸酯

分子量:616.8

分子式:C₃₆H₅₆O₈

纯度:>99%

外观:见爱必信官网

保存方法:Store at -20° C

描述:

4α-Phorbol 12-myristate 13-acetate (4α-PMA) is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA , a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

应用:A phorbol ester analog, binds to TRPV4, increases PGHS-2 mRNA in murine keratinocytes

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